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New Study Shows How Creatine Impacts Squats, Chess Presses & Jumps

Molly Knudsen, M.S., RDN
Author:
September 06, 2025
Molly Knudsen, M.S., RDN
Registered Dietitian Nutritionist
By Molly Knudsen, M.S., RDN
Registered Dietitian Nutritionist
Molly Knudsen, M.S., RDN is a Registered Dietician Nutritionist with a bachelor’s degree in nutrition from Texas Christian University and a master’s in nutrition interventions, communication, and behavior change from Tufts University. She lives in Newport Beach, California, and enjoys connecting people to the food they eat and how it influences health and wellbeing.
Fit Woman Doing a Squat with a Medicine Ball
Image by Artem Varnitsin / EyeEm / Getty
September 06, 2025

Are you ready to consistently pick up heavier weights at the gym? In addition to actually starting to pick up heavier weights (this is called progressive overload) for certain sets or on days you feel great, you can also support your strength outside the gym with creatine supplements

Now, hundreds of studies have been conducted on creatine’s safety profile and benefits. There’s so much data on the supplement that researchers are pooling the data to look at more nuanced effects of the supplement. 

In this latest meta-analysis, researchers were looking at creatine's impact on lower body versus upper body strength1 and power and explored how factors like age, sex, dose, training status, and training frequency influence results. Here’s what you need to know. 

About the study

Researchers wanted to see how creatine supplementation affects different types of strength and power, and whether it helps more with upper body exercises (like the bench press) or lower body exercises (like squats, leg press, vertical jump). 

Now, it is well established that creatine is one of the most effective supplements2 for boosting exercise performance. There’s no doubt that when it’s paired with a strength training routine, it helps people build more muscle and strength than exercise alone would have.* 

Over the years, many trials and reviews have shown that creatine can improve strength and power.* But the research has been somewhat fragmented: different studies use different measures, populations, and dosing strategies, making it hard to get a clear, big-picture view.

And that’s exactly what this study aimed to do. 

Researchers analyzed and pooled data from 69 randomized controlled trials (almost 2,000 people total) that tested creatine, with or without exercise, measuring strength and power in these common exercises. And they also looked at whether age, sex, or other factors change the effects.

The goal? Provide a clearer understanding of when (and for whom) creatine works best.  

Creatine & resistance training is a winning combo

Not shocking, analysis from this study overwhelmingly showed that pairing creatine with resistance training led to the most improvements in strength and fitness.* Compared to folks just taking a placebo and lifting weights, those taking creatine could:* 

  • Bench/chest press an average of 3 pounds more
  • Squat an average of 12 pounds than their baseline weight 
  • Jump a little over half an inch higher than their norm 
  • Cycle more powerfully during a fitness test

These changes may seem small, but adding an extra 10–12 pounds to a squat or even a few pounds to a bench press can be a meaningful difference, especially over time. 

Who benefited the most? 

Further analysis of the 2,000 participants from these 69 studies revealed that people under 50 saw more significant changes than folks over 50, and men saw more significant changes than women. Why is this the case? 

Much of the sports performance research to date has been conducted in younger, male athletes, meaning women and older adults are chronically underrepresented. This makes it hard to know the true scope of benefits for these groups, especially since many of the trials weren’t designed around women’s hormonal cycles or included a less intense exercise program. 

But here’s the key: creatine may actually be even more impactful for women and older adults. 

Women tend to have lower baseline creatine levels, so supplementation could help close that gap.

And for older adults, creatine offers meaningful support for maintaining muscle mass and strength. A review article published in 2024 that specifically looked at creatine and strength training benefits in adults over 50 did found creatine supplements improved lean muscle mass, cognitive function, and bone geometry.* 

How to take creatine

The 69 studies in this analysis included a wide range of dosing strategies, but the most common and effective approach remains simple: 3 to 5 grams of creatine monohydrate per day. (Although other studies have shown that taking around 10 grams a day better supports cognition).*

You can take creatine anytime of day, it’s just important to take it daily (even on rest days!). 

There are so many creatine supplements to choose from, but a great place to start is with mindbodygreen’s creatine with taurine+. Each serving provides 5 grams of creatine monohydrate with 2 grams of the amino acid taurine to further support performance, recovery, and overall heart health.* 

If you’re also looking for hydration support, this electrolyte drink mix also provides 3 grams of creatine. 

The takeaway

Creatine is one of the most effective supplements for boosting strength and power, especially when combined with resistance training.* Up until the last 5 to 10 years, the majority of studies on creatine have been conducted in healthy young men, so it’s no surprise that this analysis showed it was that group who benefited the most. 

However, more and more studies are coming out showing that this supplement is also crucial for women’s health and for older adults3. It’s truly a supplement most people would benefit from taking.*

If you are pregnant, breastfeeding, or taking medications, consult with your doctor before starting a supplement routine. It is always optimal to consult with a health care provider when considering what supplements are right for you.